2 amino benzo f chromene grinding method

(PDF) Synthesis, Anticancer Activities and Experimental

Synthesis, Anticancer Activities and Experimental-Theoretical DNA Interaction Studies of 2-Amino-4-Phenyl-4H-benzo[h]chromene-3-carbonitrile

Ethyl 2-amino-4-(4-fluorophenyl)-6-methoxy-4H-benzo[h]chromene …

A convenient and efficient method using microwave assisted synthesis of 4H-benzo[h]chromenes (7 and 8), by the reaction of 4-methoxy-1-naphthol (1) with a mixture of aromatic aldehydes (2) and ...

Brønsted acid catalyzed mechanochemical domino …

Chromene and their derivatives, particularly 2H-chromene-2-one also known as coumarin 6, and 2-amino-4H-chromene 33, possessing cyano functionality at …

Microwave assisted synthesis of 2-amino-6-methoxy-4H-benzo[h]chromene …

A convenient and efficient method using microwave assisted synthesis of 4 H -benzo[ h ]chromenes (7 and 8), by the reaction of 4-methoxy-1-naphthol (1) with a mixture of aromatic aldehydes (2) and malononitrile (3) or ethyl cyanoacetate (5) and also, by the reaction of 4-methoxy-1-naphthol (1) with α -cyanocinnamonitriles (4) or ethyl α …

Full article: Novel benzo chromene derivatives: design, …

The scoring methods were adjusted to default values. The MDB file of the three ligands in each of the four databases was loaded and general docking calculations were run automatically. ... We focussed on two main scaffolds: 2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles 1a–c and 3-amino-1-phenyl-1H-benzo[f]chromene-2 …

[3+3] Cyclocondensation of β-carbonyl-substituted

Chemistry of Heterocyclic Compounds 2022, 58(11), 651–655 652 [4,3-a]pyrimidines as a result of Dimroth rearrangement,7as shown in Scheme 2. We have demonstrated that, in the case of 2-trifluoro-acetyl-1Н-benzo[f]chromene (1a) and 3-amino-1,2,4-tri-azole (2а), a reaction in either refluxing MeCN or in refluxing AcOH led to the …

The One-Step Synthesis of 3,4-Dihydropyrano[F]Chromene …

Table 1: 3-amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile 4a–g in under grinding using DABCO Yields refer to pure isolated products characterized b y IR, 1 H and 13 C N MR spectroscopy and mass spectrometry. The structures of compounds 4 were deduced from their 1 H NMR, 13 C NMR and IR spectral data and their molecular weight …

2H/4H-Chromenes—A Versatile Biologically …

2H/4H-chromene (2H/4H-ch) is an important class of heterocyclic compounds with versatile biological profiles, a simple structure, and mild adverse effects. Researchers discovered several routes for the synthesis …

Synthetic strategies and pharmacological activities of chromene …

However, when the molar ratio (Method B) was 1:2 and the conditions (time and temperature) were of method A, ... A series of 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives was synthesized by Rafinejad and the research group (Scheme 90). All of the compounds were tested for cell growth inhibition of breast cancer …

Convenient and Efficient One-Pot Method for the Synthesis …

A convenient and efficient one-pot method for the synthesis of 2-amino-tetrahydro-4 H -chromene and 2-amino-4H-benzo [ h ]-chromene derivatives has been …

Synthetic strategies and pharmacological activities of …

Various synthetic approaches for the synthesis of chromenes have been reported using classical and non-classical methods. Additionally, syntheses via the MCR …

Full article: Novel benzo chromene derivatives: design, …

The scoring methods were adjusted to default values. The MDB file of the three ligands in each of the four databases was loaded and general docking calculations …

Crystal structure of 2-amino-4-phenyl-4H-benzo[h]chromene …

The structural geometric parameters of the title compound are normal and are consistent with those of the isomer compound 3-amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile (Akkurt et al., 2013). Both isomers crystallizes in the same monoclinic space group P 2 1 and their unit-cell parameters are almost equal.

A facile and green three-component synthesis of 2-amino-3 …

A simple, efficient and one-pot method has been developed for the synthesis of densely functionalized aryl derivatives of 2-amino-3-cyano-7-hydroxy-4H- …

ino benzo chromene grinding method

ZnO nano-particles were prepared using the homogeneous precipitation method and 2-amino ethanol as. Read More. ... 2amino benzo f chromene grinding method. WebThe synthesis of benzogchromene derivatives through a multi-component reaction catalyzed by lipase is reported for the first time. This novel efficient method has the advantages of ...

(PDF) Solvent-free synthesis of 1-amidoalkyl-2-naphthol and 3-amino …

A green procedure for the one-pot three-component synthesis of 1-amidoalkyl-2-naphthol and 3-amino-1-phenyl-1H benzo[f]chromene-2-carbonitrile derivatives from the reaction of 2-naphtol, aldehydes ...

Green methods mediated synthesis of chromene

Effective synthesis of chromene derivatives using green methods. ... as an efficient nanocatalyst for one-pot synthesis of 2-Amino-3-cyano-7-hydroxy-4H-chromenes derivatives in water. ... Fast and efficient green procedure for the synthesis of benzo[5,6]Chromene derivatives and their sulfur analogues in water by organocatalyst …

Methods of synthesis of chromeno[2,3- b ]chromenes

Thermolysis of 2-[(dimethylamino)methyl]phenols by heating in DMF under reflux in the presence of malononitrile and DBU with the reagent ratio of 2:1:1 leads to …

Chromenes: Phytomolecules with Immense Therapeutic …

The 2H-chromene motif can fuse with the benzene ring at four possible positions (c, f, g, h), resulting in four types of benzochromenes, namely, benzo[c]chromene (1a), benzo[f]chromene (1b), benzo[g]chromene (1c) and benzo[h]chromenes (1d). Likewise, fusion of the 2H-chromene with naphthalene results in four different types of …

Crystal structure of 2-amino-4-(4-methoxyphenyl)-4H-benzo[g]chromene

In the title compound, C 21 H 16 N 2 O 2, the naphthalene fragment is twisted slightly, as indicated by the dihedral angle of 3.2 (2)° between the two six-membered rings.The pendant 4-methoxyphenyl ring makes a dihedral angle of 86.08 (6)° with the central six-membered ring of the 4H-benzo[g]chromene ring system.In the crystal, …

Recyclable mesalamine-functionalized magnetic …

The activity of the synthesized nanocatalyst was evaluated in the tandem Knoevenagel-Michael cyclocondensation of various aromatic aldehydes, dimedone and malononitrile under a dry grinding method at room temperature to provide biologically active 2-amino-4H-benzo[b]pyran derivatives products in a short time with good yields. …

Synthesis of β-Enaminonitrile-Linked 8-Methoxy-1H-Benzo[f]Chromene …

A series of aryl-substituted 3-amino-1-aryl-8-methoxy-1H-benzo[f]chromene-2-carbonitriles (4a–4q) were designed and synthesized via reaction of 6-methoxy-2-naphthol with a mixture of appropriate aromatic aldehydes and malononitrile under microwave conditions.The structures of the novel compounds 4b, 4c, 4f, 4g, 4i, 4l, …

Inhibitory activity of benzo [h]quinoline and benzo [h]chromene …

Purpose: To carry out a neat synthesis of 2-amino-5,6-dihydro-8-methoxy-4-phenylbenzo[h]quinoline-3- carbonitrile (compound 2) and 2-amino-5,6-dihydro-8-methoxy-4-phenyl-4H-benzo[h]chromene-3- carbonitrile (compound 3) and evaluate their cytotoxic activity in human glioblastoma cells. Methods: Benzo[h]quinoline and …

2-Amino-4-(3,4-diethoxy-phenyl)-4H-benzo[h]chromene-3 …

2-Amino-4-(3,4-diethoxy-phenyl)-4H-benzo[h]chromene-3-carbonitrile | C24H22N2O3 | CID 3125712 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. ... -4H-benzo[h]chromene-3-carbonitrile | C24H22N2O3 | CID …

Synthesis of β-Enaminonitrile-Linked 8-Methoxy-1H-Benzo[f]Chromene

A series of aryl-substituted 3-amino-1-aryl-8-methoxy-1H-benzo[f]chromene-2-carbonitriles (4a–4q) were designed and synthesized via reaction of 6-methoxy-2-naphthol with a mixture of appropriate aromatic aldehydes and malononitrile under microwave conditions. The structures of the novel compounds 4b, 4c, 4f, 4g, 4i, 4l, …

Brønsted acid catalyzed mechanochemical domino …

Chromene and their derivatives, particularly 2H-chromene-2-one also known as coumarin 6, and 2-amino-4H-chromene 33, possessing cyano functionality at the C-3 position, constitute such an ...